Q&A: Mikala Egeblad on tumor microenvironment.
نویسندگان
چکیده
Mikala Egeblad, PhD, who studies tumor microenvironment at New York's Cold Spring Harbor Laboratory, talks about how a tumor's microenvironment may affect therapeutic responses and disease metastasis, as well as future research directions in the field.
منابع مشابه
Cancer: Signal Transduction
Mikala Egeblad and colleagues study tumors and, in particular, the contributions of the microenvironment in which the cancer cells arise and live. Solid tumors are abnormally organized tissues that contain not only cancer cells, but also various stromal cell types and the extracellular matrix, and these latter components constitute the microenvironment. Communications between the different comp...
متن کاملImaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.
Little is known about the dynamics of cancer cell death in response to therapy in the tumor microenvironment. Intravital microscopy of chemotherapy-treated mouse mammary carcinomas allowed us to follow drug distribution, cell death, and tumor-stroma interactions. We observed associations between vascular leakage and response to doxorubicin, including improved response in matrix metalloproteinas...
متن کاملVisualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.
The tumor microenvironment consists of stromal cells and extracellular factors that evolve in parallel with carcinoma cells. To gain insights into the activities of stromal cell populations, we developed and applied multicolor imaging techniques to analyze the behavior of these cells within different tumor microenvironments in the same live mouse. We found that regulatory T-lymphocytes (Tregs) ...
متن کاملLive Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
The tumor microenvironment plays a pivotal role in tumor initiation, progression, metastasis, and the response to anti-cancer therapies. Three-dimensional co-culture systems are frequently used to explicate tumor-stroma interactions, including their role in drug responses. However, many of the interactions that occur in vivo in the intact microenvironment cannot be completely replicated in thes...
متن کاملProteolytic Cleavage and Phosphorylation of a Tumor- associated ErbB4 Isoform Promote Ligand-independent Survival and Cancer Cell Growth□D
*Medicity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, ‡Turku Postgraduate School of Biomedical Sciences, and §Department of Pathology, University of Turku, FIN-20520 Turku, Finland; Laboratory of Cancer Biology, Institute of Medical Technology, Tampere University and Tampere University Hospital, FIN-33101 Tampere, Finland; ¶Department of Anatomy, University...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer discovery
دوره 4 5 شماره
صفحات -
تاریخ انتشار 2014